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Updated: Jul 2, 2025
09:01
Extraction and Quantification of Soluble, Radiolabeled Inositol Polyphosphates from Different Plant Species using SAX-HPLC
Published on: June 26, 2020
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d-Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical
Simona Dinicola1,2, Vittorio Unfer1,3, Christophe O Soulage1,4
1The Experts Group on Inositol in Basic and Clinical Research (EGOI), Rome, Italy.
Gynecologic and Obstetric Investigation
|February 19, 2024
Summary
D-chiro-inositol, a natural molecule, shows promise for metabolic and gynecological disorders. Its insulin-sensitizing effects and other mechanisms offer potential therapeutic applications, warranting further clinical investigation.
Area of Science:
- Endocrinology
- Metabolic Science
- Gynecology
Background:
- D-chiro-inositol is a natural compound explored for its therapeutic potential.
- It is studied alongside its isomer, myo-inositol, for metabolic and gynecological conditions.
Purpose of the Study:
- To review the mechanisms and functions of D-chiro-inositol.
- To establish a foundation for its clinical application in dysmetabolism, obesity, and hormonal imbalances.
Main Methods:
- A narrative review of existing literature was performed.
Main Results:
- D-chiro-inositol functions as an insulin sensitizer.
- It inhibits aromatase transcription and modulates adipose tissue browning.
- Potential applications include PCOS, obesity, and hormonal disorders.
Conclusions:
- D-chiro-inositol's distinct mechanisms from myo-inositol are increasingly understood.
- Its insulin-sensitizing role is established.
- Further research is needed for applications in obesity and hormonal disorders.
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