Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Field Effect Transistor01:29

Field Effect Transistor

402
Field-effect transistors (FETs) are integral to electronic circuits and distinguished by their three-terminal setup: the gate, drain, and source. These transistors operate as unipolar devices, which utilize either electrons or holes as charge carriers, in contrast to bipolar transistors, which use both types of carriers. The primary function of the FET is to modulate the flow of these carriers from the source to the drain through a channel. The voltage difference between the gate and source...
402

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges in Forming Sub-10 nm Nanowires via Directed Self-Assembly for Future Applications in Silicon Nanowire Biosensors.

ACS applied bio materials·2026
Same author

Ultrasensitive Specific Detection of Anti-influenza A H1N1 Hemagglutinin Monoclonal Antibody Using Silicon Nanowire Field Effect Biosensors.

ACS applied bio materials·2025
Same author

Effects of Surface Oxygen Vacancies and Hydroxy Groups on Electrical Characteristics in Solution-Gated One-Piece Indium-Tin-Oxide-Based Field-Effect Transistors.

Langmuir : the ACS journal of surfaces and colloids·2024
Same author

Charging and Discharging of Poly(<i>m</i>-aminophenylboronic Acid) Doped with Phytic Acid for Enzyme-Free Real-Time Monitoring of Human Sweat Lactate.

ACS omega·2024
Same author

Electrical monitoring of human-serum-albumin-templated molecularly imprinted polymer nanoparticles with high affinity based on molecular charges and their visualization.

Chemical communications (Cambridge, England)·2024
Same author

Estimation of the Depletion Layer Thickness in Silicon Nanowire-Based Biosensors from Attomolar-Level Biomolecular Detection.

ACS applied materials & interfaces·2023

Related Experiment Video

Updated: Jul 2, 2025

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
09:39

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

3.3K

Signal transduction interfaces for field-effect transistor-based biosensors.

Toshiya Sakata1

  • 1Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan. sakata@biofet.t.u-tokyo.ac.jp.

Communications Chemistry
|February 19, 2024
PubMed
Summary

Field-effect transistor (FET) biosensors offer cost-effective healthcare solutions. This review details signal transduction interfaces crucial for FET biosensor performance and specificity.

More Related Videos

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.2K
Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.2K

Related Experiment Videos

Last Updated: Jul 2, 2025

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
09:39

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

Published on: March 31, 2022

3.3K
Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications
11:25

Preparation of Silicon Nanowire Field-effect Transistor for Chemical and Biosensing Applications

Published on: April 21, 2016

11.2K
Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.2K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Field-effect transistor (FET) biosensors are promising for miniaturized, cost-effective healthcare applications.
  • Diverse semiconductive materials, including 1D and 2D materials, are utilized as FET channels for biosensing.
  • The signal transduction interface is critical for converting biological events into measurable electrical signals.

Purpose of the Study:

  • To review and categorize distinctive signal transduction interfaces for FET biosensors.
  • To highlight the role of these interfaces in controlling key biosensing parameters.

Main Methods:

  • Categorization of signal transduction interfaces into chemically synthesized, physically structured, and biologically induced types.
  • Analysis of how interface design impacts biosensor performance.

Main Results:

  • Distinct signal transduction interfaces significantly influence biosensing parameters.
  • Interface characteristics directly affect specificity, selectivity, binding constant, limit of detection, signal-to-noise ratio, and biocompatibility.

Conclusions:

  • Signal transduction interfaces are pivotal in optimizing FET biosensor capabilities.
  • Tailoring interfaces is essential for advancing sensitive and selective biosensing technologies for healthcare.