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Exploring the relationship between plasma substance P and glottal incompetence in the elderly
Koichi Tsunoda1,2, Toyota Ishii3, Hiroyuki Kuroda4
1Department of Otolaryngology, NHO (National Hospital Organization) Tokyo Medical Center, Tokyo, Japan.
Heliyon
|February 20, 2024
Summary
Increased blood-plasma Substance P may indicate glottal incompetence, a voice disorder. Vocal exercises showed potential correlation between Substance P levels and maximum phonation time in patients with dysphonia.
Area of Science:
- Neurology
- Otolaryngology
- Speech-Language Pathology
Background:
- Glottal incompetence is a common cause of dysphonia.
- Reduced maximum phonation time (MPT) is a key indicator of glottal incompetence.
- The role of neuropeptides like Substance P in glottal function is not fully understood.
Purpose of the Study:
- To investigate the potential of blood-plasma Substance P levels as a biomarker for glottal incompetence.
- To explore the correlation between Substance P concentration and MPT in patients with dysphonia.
Main Methods:
- An initial study was conducted on patients with dysphonia due to glottal incompetence.
- Patients underwent six months of vocal exercises to improve glottal function.
- Plasma Substance P concentrations and MPT were measured before and after the intervention.
Main Results:
- The study aimed to detect a correlation between MPT and plasma Substance P levels.
- Preliminary findings suggested a potential link, leading to a further hypothesis.
- Hypothesized that MPT < 14s (especially <10s) in dysphonia may correlate with elevated Substance P and increased aspiration risk.
Conclusions:
- Increased blood-plasma Substance P may serve as an indicator of glottal incompetence.
- Further research is warranted in specific patient groups, including those with decreased Substance P, low Activities of Daily Living scores, and aspiration pneumonia.
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