Related Experiment Video

Updated: Jul 29, 2026

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
07:44

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

10.1K

Do Children With Osteosarcoma Benefit From Pulmonary Metastasectomy?: A Systematic Review of Published Studies and

Tristan Boam1,2, Bethan G Rogoyski3, Wajid Jawaid4

  • 1Department of Pediatric Surgery, Queens Medical Centre, Nottingham, UK.

Annals of Surgery
|February 20, 2024
PubMed

Insights

The evidence for survival benefit from pulmonary metastasectomy (PM) in pediatric osteosarcoma (OS) is weak. Studies show potential benefit but suffer from selection bias, necessitating further research with modern protocols.

Area of Science:

  • Pediatric Oncology
  • Surgical Oncology
  • Evidence-Based Medicine

Background:

  • Pulmonary metastasectomy (PM) is a standard treatment for osteosarcoma (OS).
  • Recent adult colorectal cancer trials question PM's survival benefit.
  • The role of PM in pediatric OS remains unclear.

Purpose of the Study:

  • To critically evaluate the evidence for survival benefit of PM in pediatric osteosarcoma.
  • To assess the quality of existing studies on PM for pediatric OS.

Main Methods:

  • Systematic review adhering to PRISMA guidelines.
  • Searched Medline, Embase, and clinical trial registers.
  • Included retrospective studies comparing pediatric OS patients with and without PM.

Main Results:

  • Eleven retrospective studies (1984-2017) were included.
  • No studies directly compared PM versus no PM as a primary objective.
  • High risk of bias and significant heterogeneity in patient selection were noted.
  • Reported 3-year survival rates varied widely (0-54% for PM, 0-16% for no PM).
  • Patients receiving PM often had unresectable disease or poor prognosis.

Conclusions:

  • The evidence for PM survival benefit in pediatric OS is weak (Level IV), likely due to selection bias.
  • Included studies often used outdated protocols and were not designed to directly answer the question.
  • A randomized controlled trial with modern chemotherapy is needed to definitively assess survival benefit.
Abstract

More Related Videos

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate07:31

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

3.6K
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

9.2K

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...