Related Experiment Video
Updated: Jul 2, 2025

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
Published on: February 24, 2021
Platelet-Rich Plasma: Advances and Controversies in Hair Restoration and Skin Rejuvenation
Arianne Shadi Kourosh1,2, Kathyana P Santiago Mangual1,3, Ronda S Farah4,5
1Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.
Background:
Platelet-rich plasma (PRP) and its combined therapeutic modalities have catalyzed new possibilities in dermatology; however, limitations in evidence and lack of consensus remain among clinicians regarding optimal composition, protocol, technique, and application.
Objective:
To provide an update and analysis of the evidence for PRP in hair restoration and skin rejuvenation through review of recent available data, highlighting controversies and expert insights to guide future studies, and stimulate discourse and innovations benefitting patients.
Methods:
A structured review and expert analysis of PubMed publications before October 2023, with a focus on recent literature from January 2020 through October 2023.
Results And Conclusion:
Growing literature supports the utility and benefits of PRP and related autologous products for applications for skin and hair, with strongest evidence for androgenetic alopecia and skin rejuvenation. However, this is limited by lack of consensus regarding best practices and protocols. Randomized, controlled trials with uniform metrics comparing outcomes of various compositions of autologous blood products, preparation methods, dosimetry, and frequency of treatments are still required. This will allow the medical discourse to grow beyond the realm of expert opinion into consensus, standardization, and more wide spread adoption of best practices that will benefit patients.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Renewal of Skin Epidermal Stem Cells

