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A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Mandibular Distraction Osteogenesis in Children and Adolescents: A Clinical and Radiographic Research Using Cone-Beam
Nadia Theologie-Lygidakis1, Georgios Kamperos2, Maria Pavli2
1Department of Oral and Maxillofacial Surgery, School of Dentistry, National and Kapodistrian University of Athens, and "P. & A. Kyriakou" Children's Hospital.
Mandibular distraction osteogenesis (MDO) is effective for children with facial deformities. Long-term outcomes show stability in hemifacial microsomia but some relapse in micrognathia, with CBCT aiding evaluation.
Area of Science:
- Craniofacial surgery
- Pediatric orthognathics
- Regenerative medicine
Background:
- Mandibular deformities in children require early intervention.
- Distraction osteogenesis (DO) is a surgical technique to lengthen the mandible.
- Long-term outcomes of MDO in pediatric patients need comprehensive evaluation.
Purpose of the Study:
- To assess the long-term postoperative outcomes of mandibular distraction osteogenesis (MDO) in pediatric patients.
- To evaluate the stability and esthetics of MDO results using cone-beam computed tomography (CBCT).
- To compare outcomes between hemifacial microsomia (HFM) and mandibular micrognathia cases.
Main Methods:
- A 16-year retrospective cross-sectional study of pediatric patients treated with MDO.
- Clinical and radiographic parameters were recorded.
- Cone-beam computed tomography (CBCT) was utilized for detailed assessment of bone regeneration and morphology.
Main Results:
- MDO was successful in all 11 pediatric patients (5 HFM, 6 micrognathia).
- Long-term results were stable and accepted in HFM cases.
- Relapse occurred in 4 of 6 micrognathia cases; regenerated bone shape varied between conditions, but quality was normal.
- CBCT provided detailed insights into distraction site changes.
Conclusions:
- MDO is a viable early treatment for pediatric mandibular deformities.
- Long-term MDO outcomes show growth-related relapse, particularly in micrognathia.
- CBCT is crucial for detailed evaluation of MDO treatment sites.
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