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Updated: Jul 2, 2025

A Photodynamic Approach to Study Function of Intracellular Vesicle Rupture
Published on: March 17, 2023
A novel pH-activated AIEgen probe for dynamic lysosome tracking and high-efficiency photodynamic therapy
Yingcai Hu1, Sheng-Yan Yin1, Ting Deng2
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. jishanli@hnu.edu.cn.
Abstract:
A novel AIEgen molecular probe (N-3QL) with typical AIE effects, good biocompatibility, lysosome targeting, pH activation, excellent photostability, and high brightness was synthesized using two simple synthetic steps. Spectroscopic and cytotoxicity experiments indicate that N-3QL can not only be used for the dynamic monitoring of cancer cell lysosomes, but also for photodynamic therapy (PDT) ablation of cancer cells.

