Preimplantation genetic testing in the current era, a review

Area of Science:

• Reproductive Genetics
• Embryology
• Genomics

Background:

• Preimplantation genetic testing (PGT), or preimplantation genetic diagnosis (PGD), is an IVF technology for identifying embryo genetic abnormalities before implantation.
• PGT screens embryos for chromosomal abnormalities, monogenic disorders, and structural rearrangements.

Purpose of the Study:

• To comprehensively review PGT, including its pros and cons.
• To discuss recent advancements and future perspectives in PGT.

Main Methods:

• Review of existing literature on PGT techniques and applications.
• Analysis of PGT advancements, including PGT-A, PGT-M, and PGT-SR.

Main Results:

• PGT has evolved significantly, with three main types: PGT-A (aneuploidy screening), PGT-M (monogenic disorders), and PGT-SR (structural rearrangements).
• The review covers detailed aspects of PGT, highlighting current progress.

Conclusions:

• PGT offers valuable insights into embryo genetics, aiding reproductive decisions.
• This review contributes to understanding PGT techniques and advances in reproductive genetics.