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Published on: February 15, 2022
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Glucocorticoid-Induced Ocular Hypertension and Glaucoma
Devon Hori Harvey1,2, Chenna Kesavulu Sugali1,2, Weiming Mao1,2,3,4,5
1Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Clinical Ophthalmology (Auckland, N.Z.)
|February 21, 2024
Summary
Glucocorticoid therapy can cause ocular hypertension and glaucoma. This review details the cellular changes, clinical factors, and management strategies for glucocorticoid-induced ocular hypertension and glaucoma.
Area of Science:
- Ophthalmology
- Endocrinology
- Pathology
Background:
- Glucocorticoid (GC) therapy is widely used for various diseases, including ocular conditions.
- A significant side effect is GC-induced ocular hypertension (GIOHT), potentially leading to irreversible blindness (GC-induced glaucoma, GIG).
Purpose of the Study:
- To review the pathological mechanisms underlying GIOHT at cellular and molecular levels.
- To discuss the clinical aspects of GIOHT/GIG, including prevalence, risk factors, and management.
Main Methods:
- Literature review of pathological changes in the trabecular meshwork and Schlemm's canal.
- Analysis of clinical data on GIOHT/GIG prevalence, GC types, administration routes, and treatment.
Main Results:
- Pathological changes in the trabecular meshwork and Schlemm's canal contribute to GIOHT.
- Clinical factors such as GC type, administration route, and patient risk factors influence GIOHT/GIG development.
Conclusions:
- Understanding the cellular and molecular basis of GIOHT is crucial.
- Comprehensive clinical management strategies are necessary to mitigate the risks of GIOHT/GIG.
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