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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Polymerized cyclodextrin microparticles for sustained antibiotic delivery in lung infections

Tracey L Bonfield1, Sean T Zuckerman2,3, Morgan T Sutton1,4,5

  • 1Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio, USA.

Journal of Biomedical Materials Research. Part A
|February 21, 2024
PubMed

Insights

This study shows polymerized cyclodextrin microparticles can deliver antibiotics effectively to the lungs. This novel approach offers localized, sustained treatment for chronic lung infections like those in cystic fibrosis (CF).

Area of Science:

  • Pulmonary Medicine
  • Nanotechnology
  • Infectious Diseases

Background:

  • Chronic lung diseases, such as cystic fibrosis (CF), are complicated by recurrent pulmonary infections.
  • CF airways present a unique environment with viscous mucus, promoting bacterial colonization and antibiotic resistance.
  • Current treatment strategies face challenges due to pathogen complexity and patient tolerance to drug combinations.

Purpose of the Study:

  • To explore a microparticle antibiotic delivery system for localized and sustained antibiotic dosing in pulmonary infections.
  • To demonstrate the feasibility of managing CF-related lung infections using advanced drug delivery.

Main Methods:

  • Development and testing of polymerized cyclodextrin microparticles for antibiotic delivery.
  • Evaluation of the system's efficacy using preclinical in vitro and in vivo models of CF lung infections.

Main Results:

  • The study demonstrated the feasibility of efficient, localized antibiotic delivery via microparticles.
  • Polymerized cyclodextrin microparticles proved effective in preclinical CF infection models.
  • Site-directed management of pulmonary infections was achieved.

Conclusions:

  • Polymerized cyclodextrin microparticles represent a viable strategy for targeted antibiotic delivery in pulmonary infections.
  • This approach offers a promising proof-of-concept for managing challenging lung infections in CF patients.
  • The developed microparticle system shows potential for improving treatment outcomes in chronic lung diseases.
Keywords:
Pseudomonas aeruginosacystic fibrosisgentamicininfection managementmicroparticle drug‐releasepiperacillintazobactamvancomycin

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