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Raman and Surface-Enhanced Raman Scattering Detection in Flowing Solutions for Complex Mixture Analysis
Monika Poonia1, Courtney J Morder1, Hannah C Schorr1
1Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio, USA;
Annual Review of Analytical Chemistry (Palo Alto, Calif.)
|February 21, 2024
Summary
Raman spectroscopy and surface-enhanced Raman scattering (SERS) offer label-free analysis of flowing liquids. These techniques, coupled with microfluidics and separations, enable versatile chemical detection in complex mixtures.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Chemical Analysis
Background:
- Raman scattering is a label-free technique for chemical identification and quantification.
- Flowing liquid analysis presents unique challenges for spectroscopic methods.
- Surface-enhanced Raman scattering (SERS) amplifies Raman signals for enhanced sensitivity.
Purpose of the Study:
- To review the applications of Raman spectroscopy and SERS for flowing liquid samples.
- To examine advancements in online and at-line detection strategies.
- To highlight challenges, limitations, and future potential of these techniques.
Main Methods:
- Comprehensive review of literature on Raman and SERS for flowing solutions.
- Analysis of microfluidic device designs and SERS substrate development.
- Examination of sampling interfaces and coupling with chemical separations (chromatography, electrophoresis).
Main Results:
- Raman and SERS are effective for analyzing complex mixtures in flowing systems.
- Integration with microfluidics and separation techniques enhances analytical capabilities.
- Various applications demonstrated across chemistry, biology, and environmental science.
Conclusions:
- Raman spectroscopy and SERS are powerful tools for real-time chemical analysis of liquids.
- Further optimization holds significant promise for broader applications.
- These label-free methods offer a versatile approach to molecular identification and quantification.
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