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Updated: Jul 2, 2025
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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
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Cannabinoid Use and Obstructive Sleep Apnea: A Retrospective Cohort Study
Matthew R Veitch1,2, Sean Jairam1, Patrick Gurges1,2
1Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Summary
Cannabis use did not significantly alter obstructive sleep apnea (OSA) severity in a large study. However, in severe cases, cannabis use impacted sleep stages, increasing deep sleep and decreasing REM sleep.
Area of Science:
- Sleep Medicine
- Pharmacology
Background:
- Obstructive sleep apnea (OSA) lacks effective pharmacological treatments.
- Cannabinoids show potential for reducing OSA severity in preliminary human studies.
Purpose of the Study:
- To investigate the association between self-reported cannabis use and OSA severity.
- To analyze the impact of cannabis on sleep parameters using polysomnography data.
Main Methods:
- Retrospective cohort study of adults undergoing polysomnography (2010-2022).
- Multivariable linear regression models adjusted for age, sex, BMI, medications, and comorbidities.
- Exploratory subgroup analysis in patients with moderate to severe OSA.
Main Results:
- Cannabis use was not associated with OSA severity after full adjustment.
- In moderate to severe OSA patients, cannabis use was linked to increased stage N3 sleep and decreased REM sleep.
Conclusions:
- Cannabis use does not appear to influence overall OSA severity when confounding factors are considered.
- Cannabis use may alter sleep architecture in patients with moderate to severe OSA.
- Further research is warranted to explore these sleep architecture changes.
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