Association of vitamin D receptor gene polymorphisms with breast cancer risk
Shruti R Patel1, Kinjal D Patel1, Jayendra B Patel1
1Biochemistry Research Division, Department of Cancer Biology, The Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.
Journal of Cancer Research and Therapeutics
|February 22, 2024
Summary
Vitamin D receptor (VDR) gene polymorphisms, specifically the Poly A variant, are linked to increased breast cancer risk. Other VDR gene variants showed no significant association with breast cancer risk in this study population.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Emerging research indicates vitamin D signaling may offer protection against breast cancer.
- Investigating the role of vitamin D receptor (VDR) gene variations in breast cancer susceptibility is crucial.
Purpose of the Study:
- To examine the association between VDR gene polymorphisms and breast cancer risk.
- To determine if specific VDR gene variants influence susceptibility to breast cancer.
Main Methods:
- Genotyping of VDR gene polymorphisms (Fok1, Bsm1, Apa1, Taq1, and Poly A) was conducted using PCR-RFLP and PCR-SSCP.
- The study included 140 breast cancer patients and 155 healthy controls from the West Indian population.
Main Results:
- The homozygous variant (LL) and heterozygous variant (SL) genotypes of the VDR Poly A polymorphism were significantly associated with an increased risk of breast cancer (OR = 5.42 and OR = 3.89, respectively).
- No significant association was found between Fok1, Bsm1, Apa1, and Taq1 polymorphisms of the VDR gene and breast cancer risk.
Conclusions:
- The Poly A polymorphism in the 3' untranslated region (UTR) of the VDR gene is significantly associated with breast cancer risk.
- These findings highlight the potential role of VDR gene variations in breast cancer etiology within the West Indian population.
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