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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Related Experiment Video

Updated: Jul 2, 2025

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
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Digestive problems in rabbit production: moving in the wrong direction?

Malou van der Sluis1, Yvonne R A van Zeeland2, Karel H de Greef1

  • 1Wageningen Livestock Research, Wageningen University & Research, Wageningen, Netherlands.

Frontiers in Veterinary Science
|February 22, 2024
PubMed
Summary
This summary is machine-generated.

Digestive issues in rabbits stem from either pathogen involvement or non-specific enteropathies. This review explores two pathways: "overload" from excess fermentable substrate and "chyme jam" from reduced motility, impacting rabbit gut health.

Keywords:
Oryctolagus cuniculusdysbiosisepizootic rabbit enteropathyfiberfusus coligastrointestinal diseasenutrition

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Area of Science:

  • Veterinary Medicine
  • Animal Science
  • Gastroenterology

Background:

  • Digestive problems are a major cause of losses in meat rabbit production.
  • Both pathogenic and non-specific enteropathies are prevalent, with unclear early pathophysiological mechanisms.
  • Factors like nutrition, genetics, and housing contribute to digestive issues.

Purpose of the Study:

  • To elucidate the derailment of normal gastrointestinal functioning in rabbits.
  • To present an integrated conceptual view of digestive problem development.
  • To shed light on the mechanisms behind non-specific enteropathies.

Main Methods:

  • Review of existing literature on rabbit digestive physiology and pathology.
  • Conceptualization of two main pathways: "overload" and "chyme jam".
  • Discussion of the role of the fusus coli and empirical evidence.

Main Results:

  • Two interacting pathways, "overload" and "chyme jam", are proposed to explain digestive derangements.
  • "Overload" involves hyperfermentation due to excess easily fermentable substrate.
  • "Chyme jam" results from reduced hindgut motility and increased digesta retention time.

Conclusions:

  • The proposed pathways offer a framework for understanding rabbit digestive diseases, including epizootic rabbit enteropathy (ERE).
  • The particle size of fiber and the fusus coli appear critical for normal colonic function.
  • Further research into these mechanisms can improve rabbit gastrointestinal resilience.