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Published on: July 5, 2024
Organometallic modification confers oligonucleotides new functionalities
Tharun K Kotammagari1, Lange Yakubu Saleh1, Tuomas Lönnberg1
1Department of Chemistry, University of Turku, Henrikinkatu 2, 20500 Turku, Finland. tuanlo@utu.fi.
Abstract:
To improve their properties or to introduce entirely new functionalities, the intriguing scaffolds of nucleic acids have been decorated with various modifications, most recently also organometallic ones. While challenging to introduce, organometallic modifications offer the potential of expanding the field of application of metal-dependent functionalities to metal-deficient conditions, notably those of biological media. So far, organometallic moieties have been utilized as probes, labels and catalysts. This Feature Article summarizes recent efforts and predicts likely future developments in each of these lines of research.
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