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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

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Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

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Published on: November 17, 2014

An Emerging Issue: Carbapenem-Resistant Enterobacteriaceae in Solid-Organ Transplantation.

Tuğba Yanık Yalçın¹, Nuran Sarı, Çağla Sarıkaş

¹From the Department of Infectious Disease and Clinical Microbiology, Baskent University Faculty of Medicine, Ankara, Turkey.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation

|February 22, 2024

Summary

Carbapenem resistance in Enterobacteriaceae bloodstream infections significantly increased in solid-organ transplant recipients after 2020. Hospitalization duration and recent prior hospitalization are key risk factors for these resistant infections.

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Last Updated: Jul 2, 2025

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation

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Published on: November 17, 2014

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

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TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

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Area of Science:

Infectious Diseases
Transplant Medicine
Antimicrobial Resistance

Background:

Bloodstream infections caused by carbapenem-resistant bacteria are a growing global health concern.
Solid-organ transplant recipients face a higher risk of these severe infections.

Purpose of the Study:

To compare clinical outcomes of carbapenem-susceptible and carbapenem-resistant Enterobacteriaceae bloodstream infections.
To identify risk factors for carbapenem resistance in solid-organ transplant recipients.

Main Methods:

Retrospective descriptive study of solid-organ transplant recipients (age ≥18) from 2015-2022.
Analysis of Enterobacteriaceae-positive blood cultures from medical records.
Identification of risk factors using logistic regression.

Main Results:

Carbapenem resistance rates increased from 15.8% before 2020 to 39.5% after 2020 (P = .007).
Significant risk factors included high Pitt bacteremia score, Charlson comorbidity index, chronic liver disease, septic shock, hypotension, delayed bacteremia onset, recent hospitalization, and prior invasive procedures.
Independent risk factors for carbapenem resistance were bacteremia ≥48 hours post-hospitalization and hospitalization within the past 3 months.

Conclusions:

A significant rise in carbapenem resistance among Enterobacteriaceae bloodstream infections in transplant recipients was observed.
Bacteremia developing ≥48 hours post-hospitalization and recent prior hospitalization are critical risk factors.
Emphasizing infection control, minimizing hospitalization duration, and adherence to prevention methods are crucial for managing these nosocomial infections.