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Correlation between double-stranded DNA and acute urticaria.

Yuanyuan Li1,2, Zhuo Li1,2, Jiayi Lu1,2

  • 1Department of Dermatology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

International Journal of Dermatology
|February 22, 2024
PubMed
Summary

Serum double-stranded DNA (dsDNA) levels are elevated in acute urticaria patients and correlate with environmental factors like temperature and UV index. This finding suggests new therapeutic targets for this common skin condition.

Keywords:
AIM2acute urticariadouble‐stranded DNAdsDNAseasontemperature

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Area of Science:

  • Immunology
  • Dermatology
  • Environmental Health

Background:

  • Acute urticaria is a common inflammatory skin condition with symptoms like wheals and itching.
  • The role of double-stranded DNA (dsDNA) in acute urticaria pathogenesis is not well understood.
  • Autoimmunity is known to involve dsDNA, but its specific link to acute urticaria requires investigation.

Purpose of the Study:

  • To investigate serum dsDNA levels in acute urticaria patients.
  • To explore the relationship between dsDNA levels and environmental factors (temperature, UV index, season).
  • To examine the expression of dsDNA receptors and related inflammatory pathways in patients.

Main Methods:

  • Serum dsDNA levels were measured in patients with acute urticaria and control groups.
  • Meteorological data (temperature, UV index, season) were correlated with disease onset dates.
  • Quantitative PCR was used to assess gene expression of dsDNA receptors, ssRNA receptors, exosome formation, and type I interferon.

Main Results:

  • Patients with acute urticaria had significantly higher serum dsDNA levels compared to controls.
  • Elevated dsDNA levels were associated with higher environmental temperatures, UV indices, and summer months.
  • Gene expression for dsDNA receptors, ssRNA receptors, AIM2-related factors, and interferon alpha was upregulated in patients.

Conclusions:

  • Serum dsDNA levels are elevated in acute urticaria and influenced by climatic factors.
  • Elevated dsDNA promotes AIM2-related factors and type I interferon expression.
  • These findings propose new hypotheses for acute urticaria pathogenesis and identify potential therapeutic targets.