Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PFAS in Fast Foods with Hot-Contact to Food-Contact Materials: Occurrence, Packaging Influence, and Risk Priority.

Environmental science & technology·2026
Same author

Correction: Associations of adverse childhood experiences and depressive symptoms among children and adolescents: the mediating effect of resilience and sleep quality.

Scientific reports·2026
Same author

Chemical emissions from organic light-emitting diode screens during use and thermal treatment.

Environmental science. Processes & impacts·2026
Same author

Legacy and Emerging Per- and Polyfluoroalkyl Substances (PFAS) in Glacial Meltwater from Mt. Everest.

Environmental science & technology·2026
Same author

Epidermal METTL1-Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Real-Time Label-Free Monitoring of Nanoparticle-Cell Interactions in Single <i>Tetrahymena thermophila</i> by Mass Cytometry.

Analytical chemistry·2026
Same journal

M2 Macrophage-Derived ENPP2/LPA Signalling Attenuates UVB-Induced Fibroblast Photoaging via LPAR1/3.

Experimental dermatology·2026
Same journal

Human-Relevant In Vitro Skin Models: From Regulatory-Validated Platforms to Emerging Technologies for Translational Dermatology.

Experimental dermatology·2026
Same journal

Large-Scale Cohort Study on the Genetic and Phenotypic Findings of Palmoplantar Keratodermas in the Chinese Population.

Experimental dermatology·2026
Same journal

52nd Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF).

Experimental dermatology·2026
Same journal

Adverse Event Profile of Apremilast: Pharmacovigilance Study Based on FDA Adverse Event Reporting System (FAERS).

Experimental dermatology·2026
Same journal

Clinical and Immunological Characteristics of Bullous Pemphigoid Patients With Psoriasis Comorbidity: A Retrospective Study.

Experimental dermatology·2026
See all related articles

Related Experiment Video

Updated: Jun 21, 2026

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

Serum DSDNA is Associated With Psoriasis.

Qi Zhen1,2, Na Yin1, Weiwei Chen1,2

  • 1North China University of Science and Technology Affiliated Hospital, Thangshan, China.

Experimental Dermatology
|June 19, 2026
PubMed
Summary
This summary is machine-generated.

Serum double-stranded DNA (dsDNA) levels are significantly higher in psoriasis patients, indicating its potential as a biomarker for disease risk and severity. Elevated dsDNA is linked to increased psoriasis odds and morbidity.

Keywords:
biomarkerdouble‐stranded DNApsoriasis

More Related Videos

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Related Experiment Videos

Last Updated: Jun 21, 2026

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate
10:05

Simultaneous Distinction of Monospecific and Mixed DFS70 Patterns During ANA Screening with a Novel HEp-2 ELITE/DFS70 Knockout Substrate

Published on: January 17, 2018

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Immunology
  • Dermatology
  • Biomarker Discovery

Background:

  • Psoriasis is a chronic autoimmune condition with unknown triggers.
  • Identifying reliable biomarkers for psoriasis risk and severity is crucial.

Purpose of the Study:

  • To investigate the association between serum double-stranded DNA (dsDNA) levels and psoriasis.
  • To evaluate dsDNA as a potential biomarker for psoriasis risk and severity.

Main Methods:

  • A multicenter case-control study involving 3,069 psoriasis patients and 7,041 healthy controls in China.
  • Analysis of serum dsDNA levels and their correlation with psoriasis diagnosis, risk, and clinical severity scores (PASI, BSA).

Main Results:

  • Serum dsDNA levels were significantly elevated in patients with psoriasis compared to controls.
  • Each 0.1 ng/mL increase in serum dsDNA correlated with a 1.45-fold increase in psoriasis odds (p < 0.001).
  • A dsDNA cutoff of 1.11 ng/mL showed 61.6% sensitivity and 74.8% specificity for psoriasis diagnosis, with a dose-response relationship observed for morbidity.

Conclusions:

  • Serum dsDNA is a potential biomarker strongly associated with psoriasis.
  • Elevated serum dsDNA levels correlate with increased psoriasis risk, morbidity, and disease severity.