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Related Experiment Video

Updated: Jul 2, 2025

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Working Memory Training for Older Participants: A Control Group Training Regimen and Initial Intellectual Functioning Assessment

Published on: September 20, 2020

White Matter Plasticity Underpins Cognitive Gains After Multidomain Adaptive Computerized Cognitive Training.

Xiangwei Dai^1,2, Sihan Liu³, Yumeng Li²

¹Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|February 22, 2024

Summary

Computerized cognitive training (CCT) improved cognitive function and white matter neuroplasticity in older adults. This home-based intervention effectively counteracted cognitive decline, showing lasting benefits.

Keywords:

Cognitive aging Computerized cognitive training Executive function Neuroplasticity White Matter

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Area of Science:

Neuroscience
Gerontology
Cognitive Psychology

Background:

Cognitive decline is a significant concern in aging populations.
White matter (WM) integrity and neuroplasticity are crucial for cognitive function.
Computerized cognitive training (CCT) is a potential intervention to mitigate age-related cognitive changes.

Purpose of the Study:

To evaluate the effectiveness of a home-based, multidomain, adaptive CCT program.
To investigate the impact of CCT on white matter (WM) neuroplasticity.
To assess changes in neuropsychological performance in older adults undergoing CCT.

Main Methods:

128 community-dwelling older adults were randomized into CCT or control groups.
The intervention group engaged in 1-year of home-based, adaptive CCT (30 min, 2x/week).
Neuropsychological tests and diffusion/T1-weighted MRI were conducted pre- and post-intervention.

Main Results:

Significant improvement in the Stroop Color-Word Test (SCWT) in the CCT group versus decline in the control group.
Increased axial diffusivity in the left posterior thalamic radiation in the CCT group, correlated with reduced SCWT reaction time.
No significant changes in gray matter volume were observed between groups.

Conclusions:

Multidomain adaptive CCT is effective and feasible for counteracting cognitive decline in older adults.
WM neuroplasticity, specifically changes in axial diffusivity, underlies the cognitive benefits of CCT.
This study elucidates the neural mechanisms supporting CCT's positive effects on cognition in aging.