Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A BASIC computer program for evaluating the effect of sample distribution on the least-squares regression slope

C A Parvin

    Computers and Biomedical Research, an International Journal
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts.

    American journal of physiology. Cell physiology·2002
    Same author

    Inhibition of sorbitol dehydrogenase exacerbates autonomic neuropathy in rats with streptozotocin-induced diabetes.

    Journal of neuropathology and experimental neurology·2002
    Same author

    Falsely increased i-STAT chloride results for blood samples with increased urea.

    Clinical chemistry·2001
    Same author

    Evaluation of the TAS analyzer and the low-range heparin management test in patients undergoing extracorporeal membrane oxygenation.

    Clinical chemistry·2001
    Same author

    Correction of positive bias of the Roche Tina-quant II hemoglobin A1c (HbA1c) assay at low HbA1c percentages.

    Clinical chemistry·2001
    Same author

    Effect of NGF and neurotrophin-3 treatment on experimental diabetic autonomic neuropathy.

    Journal of neuropathology and experimental neurology·2001

    Least-squares regression is common in method comparison studies but often violates assumptions. A new program helps determine if least-squares is appropriate by evaluating slope estimate bias based on method precision and sampling.

    Area of Science:

    • Analytical Chemistry
    • Statistical Modeling

    Background:

    • Least-squares regression is frequently employed in analytical method comparison.
    • Model assumptions for least-squares regression are often violated in these studies.
    • Despite violations, least-squares offers well-developed theory and straightforward calculations.

    Purpose of the Study:

    • To provide a tool for investigators to assess the applicability of least-squares regression.
    • To evaluate the bias of the least-squares slope estimate in method comparison scenarios.

    Main Methods:

    • Development of a BASIC computer program.
    • The program evaluates least-squares slope estimate bias.
    • Bias assessment is based on analytical method precision and sampling distribution.

    Related Experiment Videos

    Main Results:

    • The developed program quantifies bias in least-squares slope estimates.
    • It considers the interplay between method precision and experimental design.
    • Provides a quantitative basis for deciding on least-squares appropriateness.

    Conclusions:

    • The computer program aids in determining the acceptable application of least-squares regression.
    • It addresses the common issue of violated assumptions in analytical method comparisons.
    • Facilitates more rigorous and informed statistical choices in method validation.