Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

784
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
784
Neurulation01:30

Neurulation

41.9K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maternal separation increases anxiety-like phenotypes, fear responses, and alters <i>Bdnf</i> methylation in a predator odor exposure model of early life adversity.

Neurobiology of stress·2026
Same author

Vocal repertoire of adult domestic pigs in a laboratory environment.

bioRxiv : the preprint server for biology·2026
Same author

Treadmill Stepping in Newborn Rats.

bioRxiv : the preprint server for biology·2026
Same author

Early Life Food Desert Status Is Associated With Alpha and Gamma-Tocopherol Levels and Infant Lung Function.

Pediatric pulmonology·2026
Same author

Effects of Therapeutic Antibiotic Exposure on the Oropharyngeal and Fecal Microbiota in Infants With Cystic Fibrosis.

Pediatric pulmonology·2025
Same author

Gene Expression After Exercise Is Disrupted by Early-Life Stress.

Developmental psychobiology·2025
Same journal

Maternal Early Pregnancy Tetrahydrocannabinol (THC) Metabolites Correlate With Newborn Resting-State Functional Connectivity.

Developmental psychobiology·2026
Same journal

Navigating Stress: Exploring the Role of Empathy in Caregiving.

Developmental psychobiology·2026
Same journal

Children With Idiopathic Toe Walking Display Different Cortical Activation Patterns When Interpreting Tactile Sensation.

Developmental psychobiology·2026
Same journal

Epigenetic Mechanisms Linking Maternal Stress During Pregnancy to Autism Spectrum Disorders: A Narrative Review.

Developmental psychobiology·2026
Same journal

Quantifying Visuomotor Maturation From Middle Childhood to Adolescence.

Developmental psychobiology·2026
Same journal

Activational Effects of Gonadal Hormones on Social Reward Motivation in Adolescence and Adulthood in Female and Male Long-Evans Rats.

Developmental psychobiology·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2025

A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

12.5K

Epigenetic processes associated with neonatal spinal transection.

Nicholas J Collins1, Taylor S Campbell1, Aimee L Bozeman2

  • 1Department of Psychological and Brain Sciences, University of Delaware, Newark, Delaware, USA.

Developmental Psychobiology
|February 22, 2024
PubMed
Summary
This summary is machine-generated.

Spinal cord injury (SCI) alters brain-derived neurotrophic factor (BDNF) gene methylation and expression during development. Epigenetic changes in the BDNF gene may serve as a biomarker for SCI outcomes and treatment effectiveness.

Keywords:
Bdnfdevelopmentepigeneticsneurotrophinplasticityspinal cord injury

More Related Videos

Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery
07:27

Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery

Published on: June 30, 2021

2.0K
Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats
08:46

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

Published on: March 24, 2020

15.2K

Related Experiment Videos

Last Updated: Jul 2, 2025

A Neonatal Mouse Spinal Cord Compression Injury Model
13:31

A Neonatal Mouse Spinal Cord Compression Injury Model

Published on: March 27, 2016

12.5K
Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery
07:27

Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery

Published on: June 30, 2021

2.0K
Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats
08:46

Spinal Cord Lateral Hemisection and Asymmetric Behavioral Assessments in Adult Rats

Published on: March 24, 2020

15.2K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Epigenetics

Background:

  • Spinal cord injury (SCI) impacts spinal cord plasticity, partly mediated by brain-derived neurotrophic factor (BDNF).
  • BDNF delivery shows promise in mitigating SCI consequences.
  • Previous research identified epigenetic changes in the BDNF gene following SCI.

Purpose of the Study:

  • To investigate locus-specific epigenetic modifications and expression patterns of the BDNF gene during early development after SCI.
  • To determine if BDNF gene epigenetic activity can serve as a biomarker for SCI etiology and therapeutic intervention.

Main Methods:

  • Neonatal rats (P1) received thoracic spinal cord lesions.
  • Cervical and lumbar spinal cord tissues were collected at P7, P14, and P21.
  • BDNF expression, locus-specific methylation (exon IX and IV), and global methylation levels were quantified.

Main Results:

  • SCI induced locus-specific reductions in BDNF expression, correlated with increased methylation caudal to the injury.
  • Elevated BDNF expression was observed at the P14 timepoint.
  • Global methylation levels were also assessed across timepoints.

Conclusions:

  • Epigenetic regulation of the BDNF gene is altered following developmental SCI.
  • BDNF gene methylation patterns may act as a biomarker for understanding SCI progression.
  • These epigenetic markers could inform the efficacy of interventions for spinal cord injury.