Related Experiment Video
Updated: Jul 2, 2025
04:19
A Computer-Based Platform for Aiding Clinicians in Eating Disorder Analysis and Diagnosis
Published on: May 10, 2022
3.8K
Let's get aligned! Developing a core outcome set for clinical trials in eating disorders
Anna Victoria Brieva-Toloza1, Oliver Rumle Hovmand2,3, Nadia Micali1,4
1Eating Disorders Research Unit, Psychiatric Centre Ballerup, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Summary
The wide variety of outcome measures in eating disorder (ED) clinical trials makes comparing results difficult. Developing a standardized core outcome set is recommended for better data integration in ED research.
Area of Science:
- Psychiatry
- Clinical Psychology
- Health Services Research
Background:
- Randomized controlled trials (RCTs) are crucial for evaluating eating disorder (ED) treatments.
- A lack of standardized outcome measures complicates the interpretation and comparison of findings across ED RCTs.
Purpose of the Study:
- To systematically review outcome measures used in ED RCTs.
- To assess the heterogeneity and homogeneity of these assessment instruments.
Main Methods:
- Searched APA PsycInfo, PubMed, and Embase (Jan 2012–Dec 2022).
- Included peer-reviewed RCTs of Anorexia Nervosa, Binge Eating Disorder, or Bulimia Nervosa using standardized psychometric instruments.
- Collected data on 196 distinct outcome measures from 91 included articles.
Main Results:
- A substantial number of outcome measures (196) were identified across 91 studies.
- Significant heterogeneity exists in the assessment instruments employed in ED RCTs.
Conclusions:
- The diversity of outcome measures hinders comparability and data integration in ED research.
- A Delphi-method-based core outcome measure set, incorporating clinician and patient-reported ED and comorbidity assessments, is proposed.
Related Concept Videos
01:23Binge Eating Disorders
68
Binge eating disorder is a significant mental health condition characterized by recurrent episodes of excessive food consumption within a short period, accompanied by a perceived loss of control over eating behavior. Unlike occasional overeating, binge eating disorder is marked by distressing emotions such as guilt, shame, and anxiety following binge episodes. The disorder affects individuals across different ages and backgrounds, with profound implications for physical and psychological...
68
01:11Clinical Trials: Overview
2.9K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
2.9K
01:30Bulimia Nervosa
78
Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...
78
01:16Clinical Trials
6.7K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.7K
01:28Anorexia Nervosa
68
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
68
01:20Study Designs in Epidemiology
217
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
217