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Related Concept Videos

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches01:14

Analysis Methods of Pharmacokinetic Data: Model and Model-Independent Approaches

Drug disposition in the body is a complex process and can be studied using two major approaches: the model and the model-independent approaches.
The model approach uses mathematical models to describe changes in drug concentration over time. Pharmacokinetic models help characterize drug behavior in patients, predict drug concentration in the body fluids, calculate optimum dosage regimens, and evaluate the risk of toxicity. However, ensuring that the model fits the experimental data accurately...
Model Approaches for Pharmacokinetic Data: Compartment Models01:14

Model Approaches for Pharmacokinetic Data: Compartment Models

Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This relationship...
Pharmacokinetic Models: Comparison and Selection Criterion01:26

Pharmacokinetic Models: Comparison and Selection Criterion

Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Methods of Medium Optimization01:28

Methods of Medium Optimization

Optimizing growth media enhances microbial proliferation and maximizes product yield. Statistical experimental design methodologies provide structured and reproducible approaches, offering progressively higher levels of robustness and efficiency.The One-Factor-at-a-Time (OFAT) MethodThe One-Factor-at-a-Time (OFAT) method involves adjusting a single variable while keeping all others constant. However, it cannot detect interactions between variables, often leading to suboptimal outcomes when...

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Knowledge Based Cloud FE Simulation of Sheet Metal Forming Processes
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A Novel Framework of Developing a Predictive Model for Powder Bed Fusion Process.

Mallikharjun Marrey1,2, Ehsan Malekipour1,2, Hazim El-Mounayri1,2

  • 1Department of Mechanical and Energy Engineering, Purdue University, Indianapolis, Indiana, USA.

3D Printing and Additive Manufacturing
|February 23, 2024
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Summary

This study introduces a new framework for powder bed fusion (PBF) additive manufacturing, enabling precise control over process parameters to optimize 316L stainless steel properties for high density and superior mechanical performance.

Keywords:
additive manufacturingintelligent parameters selectionmechanical propertiesneural networkoptimal energy densityoptimization frameworkpowder bed fusionpredictive models

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Area of Science:

  • Materials Science and Engineering
  • Additive Manufacturing
  • Computational Modeling

Background:

  • Powder bed fusion (PBF) is a versatile metal additive manufacturing technique.
  • Current PBF research often lacks a systematic approach for modeling numerous parameters simultaneously.
  • Optimizing PBF requires quantitative methods to link process parameters to material properties and final part quality.

Purpose of the Study:

  • To develop a predictive modeling framework for PBF of 316L stainless steel.
  • To establish correlations between laser specifications, volumetric energy density, and mechanical properties.
  • To enable intelligent selection of process parameters for desired part performance.

Main Methods:

  • A two-phase framework for studying PBF process parameters.
  • Development of predictive models using support vector regression, random forest regression, and neural networks.
  • Analysis of correlations between laser parameters, volumetric energy density, and material properties.

Main Results:

  • Achieved high part density up to 99.31% with optimized parameters.
  • Demonstrated predictive models with approximately 10% error.
  • Identified an optimal volumetric energy density range for enhanced mechanical properties.

Conclusions:

  • The proposed framework and predictive models facilitate efficient PBF process optimization.
  • Intelligent parameter selection leads to improved density, microstructure uniformity, hardness, and impact strength.
  • This approach enables the production of high-quality 316L stainless steel parts meeting specific performance requirements.