Ligand-free Pd-catalyzed highly selective arylation of activated and unactivated alkenes via oxidative and reductive
Mixiang Tian1, Qinghong Cui1, Qiuling Xu1
1Center for Scientific Research, Yunnan University of Chinese Medicine Kunming Yunnan 650500 P. R. China wangjunliangedu@163.com sunruifen@ynutcm.edu.cn.
Abstract:
In this work, an eco-friendly, green, efficient approach for oxidative and reductive Heck-Mizoroki (HM) reactions was developed, which offered acceptable yields from first-pass experiments. Mono-arylation was achieved without the use of ligands, directing groups, or prefunctionalized alkenes. Considering mild reaction conditions, good functional group compatibility, and great regioselectivity, the method can find broad applications in novel medicine and material development and discovery processes.
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