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Updated: Jul 2, 2025
Modeling Chemotherapy Resistant Leukemia In Vitro
Published on: February 9, 2016
[Impact of acute lymphoblastic leukemia on the microbiome and oral lesions: scoping review]
Olga Leticia García Rico1, Juan Gerardo Sánchez Medina1, Elizabeth Sánchez Becerra1
1Clínica de diagnóstico, Laboratorio de Bioquímica, Microbiología y PatologíaFacultad de Estomatología, Universidad Autónoma de San Luis Potosí. San Luis. Potosí, México. leti095@outlook.com, juan_gerardo@hotmail.es, aelizabeth.sanchezb@gmail.com, sarayaranda@fest.uaslp.mx Universidad Autónoma de San Luís Potosí Clínica de diagnóstico, Laboratorio de Bioquímica, Microbiología y Patología Facultad de Estomatología Universidad Autónoma de San Luis Potosí San Luis. Potosí Mexico leti095@outlook.com juan_gerardo@hotmail.es aelizabeth.sanchezb@gmail.com sarayaranda@fest.uaslp.mx.
Objective:
To describe the existing knowledge about the alterations of the MBO oral microbiome and the presence of OL Oral Lesions in patients with Acute Lymphoblastic Leukemia ALL.
Materials And Methods:
An electronic search was carried out in the PubMed, SciELO, and academic Google databases, and descriptive, analytical, observational articles on MBO, OL, and ALL were included, following the PRISMA criteria. 642 were evaluated, duplicate articles, case reports, and those where only changes were reported during or after chemotherapy treatment were eliminated.
Results:
10 articles were evaluated, published between 1997 and 2021, 4 articles agreed that the MBO of patients with ALL is in dysbiosis showing a significant increase in firmicutes 0.1%, bacillus 0.05%, and opportunistic bacteria such as Moraxella spp, Klebsiella spp 5.66%, Pseudomonas spp 3.77%, Enterobacter spp 1.88%, Acinetobacter spp 1.88% and E. coli 1.08%, the most frequent OL reported in 5 articles were spontaneous gingival bleeding 3.5%, gingivitis 25% and ulcers 9.4%.
Conclusions:
The oral cavity of patients with ALL is in dysbiosis and associated OL is identified. It is necessary to establish preventive strategies with a niche-ecological approach to restore the MBO, to reduce the risk of opportunistic infections and other OL during chemotherapy treatment.
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