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Association of Cannabis Use Disorder with Major Adverse Cardiac and Cerebrovascular Events in Older Non-Tobacco

Avilash Mondal1, Sriharsha Dadana2, Poojan Parmar3

  • 1Department of Internal Medicine, Nazareth Hospital, Philadelphia, PA 19152, USA.

Medical Sciences (Basel, Switzerland)
|February 23, 2024
PubMed

Insights

Older adults with cardiovascular disease risk using cannabis experienced a 20% higher likelihood of major adverse cardiac and cerebrovascular events (MACCE). This highlights the cardiovascular risks associated with cannabis use disorder (CUD) in this population.

Area of Science:

  • Cardiology
  • Geriatrics
  • Public Health

Background:

  • Tobacco use disorder (TUD) negatively affects older patients with cardiovascular disease (CVD) risk.
  • Cardiovascular (CV) risk in chronic cannabis users without TUD confounding is understudied.
  • Investigating CV risk in older adults with established CVD risk factors and cannabis use disorder (CUD).

Purpose of the Study:

  • To determine the risk of major adverse cardiac and cerebrovascular events (MACCE) in older non-tobacco smokers with established CVD risk, comparing those with and without CUD.

Main Methods:

  • Utilized the 2019 National Inpatient Sample for hospitalized non-tobacco smokers (≥65 years) with CVD risk factors.
  • Identified patients with and without CUD using ICD-10 codes.
  • Employed multivariable logistic regression to assess MACCE odds in CUD vs. non-CUD cohorts.

Main Results:

  • CUD prevalence was 0.3% (28,535/10,708,815), with a median age of 69.
  • The CUD cohort showed higher MACCE odds (OR 1.20, 95% CI 1.11-1.29, p < 0.001).
  • Hypertension and hyperlipidemia predicted higher MACCE risk in the CUD cohort; unadjusted rates of acute myocardial infarction and stroke were elevated.

Conclusions:

  • Chronic cannabis use in older non-tobacco smokers with CVD risk is associated with a 20% increased likelihood of MACCE.
  • Cannabis use disorder (CUD) presents a significant risk factor for adverse cardiovascular and cerebrovascular events in older adults.
  • Findings underscore the importance of considering CUD in cardiovascular risk assessment for elderly patients.
Abstract

Keywords:
acute myocardial infarctioncannabis use disorder/marijuanacardiovascular disease riskmajor adverse cardiac and cerebrovascular eventsstroketobacco use disorder/smokers

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