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Updated: Jul 2, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
NaDES Application in Cosmetic and Pharmaceutical Fields: An Overview
Carla Villa1, Debora Caviglia1, Francesco Saverio Robustelli Della Cuna2
1Department of Pharmacy, Section of Drug and Cosmetic Chemistry, Viale Benedetto XV 3, 16132 Genoa, Italy.
Natural deep eutectic solvents (NaDES) offer a green, non-flammable alternative to ionic liquids for cosmetic and pharmaceutical uses. These easily prepared solvents show promise for sustainable extraction and developing advanced drug delivery systems.
Area of Science:
- Green Chemistry
- Materials Science
- Biotechnology
Background:
- Natural deep eutectic solvents (NaDES) are emerging as sustainable, non-flammable alternatives to traditional solvents like ionic liquids.
- They possess unique solubilizing properties, particularly for lipophilic compounds, expanding their application scope.
- NaDES are increasingly recognized for their potential in cosmetic and pharmaceutical industries due to their biocompatibility and ease of preparation.
Purpose of the Study:
- To provide a comprehensive overview of the current applications of NaDES in the cosmetic and pharmaceutical fields.
- To highlight the potential of NaDES as green solvents and as components in innovative delivery systems.
- To identify emerging opportunities and challenges associated with the implementation of NaDES.
Main Methods:
- Literature review focusing on studies utilizing NaDES in cosmetic and pharmaceutical contexts.
- Analysis of NaDES properties, including their preparation, stability, and interactions with bioactive compounds.
- Exploration of NaDES applications in extraction, formulation, and drug delivery systems.
Main Results:
- NaDES demonstrate significant potential for sustainable extraction of active ingredients.
- They can be effectively used in developing biocompatible and responsive drug delivery systems.
- NaDES show promise as biopolymer modifiers and stabilizing agents for various galenical formulations.
Conclusions:
- NaDES represent a versatile class of green solvents with broad applicability in cosmetics and pharmaceuticals.
- Their unique properties facilitate sustainable practices and the development of novel therapeutic and cosmetic formulations.
- Further research into NaDES can unlock new avenues for bioactive ingredient delivery and green chemical processes.
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