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The Influence of IL-11 on Cardiac Fibrosis in Experimental Models: A Systematic Review
Yarlla Loyane Lira Braga1, José Rodrigues do Carmo Neto1, Pablo Igor Ribeiro Franco1
1Department of Bioscience and Technology, Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiania 74605-450, GO, Brazil.
Journal of Cardiovascular Development and Disease
|February 23, 2024
Summary
Interleukin-11 (IL-11) plays a key role in cardiac fibrosis. IL-11 inhibition shows promise for treating heart fibrosis and preserving organ function in rodent models.
Area of Science:
- Cardiology
- Immunology
- Fibrosis Research
Background:
- Cardiac fibrosis impairs heart function, contributing to heart failure.
- Interleukin-11 (IL-11) is implicated in cardiac fibrosis, but its therapeutic potential is underexplored.
Purpose of the Study:
- To systematically review IL-11 therapies for rodent models of cardiac fibrosis.
- To assess the efficacy of IL-11 interventions in mitigating cardiac fibrosis.
Main Methods:
- Systematic review of in vivo rodent studies on cardiac fibrosis and IL-11 interventions.
- Searches conducted in PubMed, Web of Science, and Embase databases.
- Risk of bias assessed using SYRCLE guidelines.
Main Results:
- Eight studies evaluated five interventions: rhIL-11, anti-IL11, rmIL-11, LV-IL-11 + lutein, and anti-IL11RA.
- IL-11 overexpression exacerbated cardiac fibrosis.
- IL-11 inhibition demonstrated protective effects, preserving cardiac function.
Conclusions:
- IL-11 is a potential therapeutic target for cardiac fibrosis.
- Further research is needed to elucidate treatment mechanisms, safety, and immunogenicity.
