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Ciramadol. The therapeutic dose range during balanced anesthesia.
Acta Anaesthesiologica Belgica
|March 1, 1985
Summary
Ciramadol, a mixed opioid agonist-antagonist, was evaluated as an analgesic supplement for major surgery. While it showed a ceiling effect and did not fully suppress hemodynamic responses, it allowed for prompt recovery of ventilation without adverse psychotomimetic effects.
Area of Science:
- Anesthesiology
- Pharmacology
- Pain Management
Background:
- Major surgery requires effective anesthesia and analgesia.
- Opioid agonist-antagonists offer a unique pharmacological profile for pain management.
- Evaluating novel analgesics is crucial for improving surgical outcomes.
Purpose of the Study:
- To assess the efficacy of ciramadol as an analgesic supplement in balanced anesthesia for major surgery.
- To determine the required dosage and pharmacokinetic profile of ciramadol during surgical procedures.
- To evaluate the safety and side effect profile of ciramadol in a surgical setting.
Main Methods:
- A balanced anesthesia technique was employed in 14 surgical patients.
- Incremental doses of ciramadol were administered based on patient response.
- Dosage requirements were determined using time-dose curves.
Main Results:
- Mean loading dose: 2.5 ± 0.4 mg/kg; maintenance rate: 0.41 ± 0.09 mg/kg/h.
- A transformation rate of 50.4%/h suggested an analgesic ceiling effect.
- Hemodynamic responses were not fully suppressed; hypertensive episodes occurred.
- Spontaneous ventilation recovered promptly with no respiratory depression observed.
Conclusions:
- Ciramadol can supplement anesthesia but may have an analgesic ceiling.
- It allows for rapid recovery of ventilation post-surgery without psychotomimetic effects.
- Further research may be needed to optimize its use in major surgical procedures.