Polypharmacy and Associated Health Outcomes in the PARI-HD Study
Ivonne Torres-Atencio1, Maria B Carreira2, Alondra Méndez1
1Departamento de Farmacología, Facultad de Medicina, Universidad de Panamá, Panama City, Panama.
Journal of Alzheimer'S Disease : JAD
|February 23, 2024
Summary
Polypharmacy, or using multiple medications, is linked to poorer health and increased falls in older Hispanic adults. It was not associated with cognitive decline in this study.
Area of Science:
- Gerontology
- Public Health
- Pharmacology
Background:
- Polypharmacy (≥5 medications) poses risks for older adults.
- Minority populations are underrepresented in polypharmacy research.
- Understanding polypharmacy in diverse aging populations is crucial.
Purpose of the Study:
- To investigate polypharmacy's association with cognitive function, subjective health, frailty, and falls.
- Focus on Hispanic older adults in Panama.
- Address research gaps in underrepresented groups.
Main Methods:
- Community-based cohort study (PARI-HD) of dementia-free older adults.
- Neuropsychological tests for cognition; Fried criteria for frailty.
- Self-reported health and falls; regression analyses.
Main Results:
- Polypharmacy was associated with worse self-rated health and increased odds of multiple falls.
- Polypharmacy significantly increased odds of pre-frailty and frailty.
- No association found between polypharmacy and cognitive impairment.
Conclusions:
- Polypharmacy presents risks for older adults in Panama, including frailty and falls.
- Findings highlight the need for targeted interventions in this population.
- Further research can inform strategies to mitigate polypharmacy risks.
Keywords:
AgingAlzheimer’s diseaseCentral AmericaLatin Americacognitive impairmentdementiafallsfrailtypolypharmacyMore Related Videos
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