Related Experiment Video

Updated: Jul 2, 2025

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

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Bruton's Tyrosine Kinase Inhibitors: Recent Updates

Amneh Fares1,2, Carlos Carracedo Uribe1,2, Diana Martinez1,2

  • 1Memorial Healthcare System, Pembroke Pines, FL 33021, USA.

International Journal of Molecular Sciences
|February 24, 2024
PubMed

Bruton's tyrosine kinase (BTK) inhibitors have revolutionized the landscape for the treatment of hematological malignancies, solid tumors, and, recently, autoimmune disorders. The BTK receptor is expressed in several hematopoietic cells such as macrophages, neutrophils, mast cells, and osteoclasts. Similarly, the BTK receptor is involved in signaling pathways such as chemokine receptor signaling, Toll-like receptor signaling, and Fc receptor signaling. Due to their unique mechanism, these agents provide a diverse utility in a variety of disease states not limited to the field of malignant hematology and are generally well-tolerated.

Keywords:
Bruton’s kinase inhibitorsacalabrutinibautoimmune disordershematologic malignanciesibrutinibpirtobrutinibzanubrutinib

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