Frequencies of BCR::ABL1 Transcripts in Patients with Chronic Myeloid Leukemia: A Meta-Analysis
Pablo Romero-Morelos1, Ana Lilia González-Yebra2, Daniela Muñoz-López3
1Department of Research, State University of the Valley of Ecatepec, Ecatepec 55210, Mexico State, Mexico.
Genes
|February 24, 2024
Summary
The most common BCR::ABL1 transcript in Chronic Myeloid Leukemia (CML) globally is b3a2, followed by b2a2. Regional variations were minimal, with Mexico showing a similar trend, informing personalized CML treatments.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome and specific BCR::ABL1 gene transcripts.
- Understanding the prevalence of these transcripts is crucial for CML diagnosis and management.
Conclusions:
- The b3a2 transcript is the most common BCR::ABL1 transcript worldwide, a trend consistent in Mexico.
- Evaluating BCR::ABL1 transcript frequencies is clinically relevant for personalized CML treatment strategies.
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