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NADPH Oxidase 3: Beyond the Inner Ear.

Marc Herb1,2,3

  • 1Institute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine, University Hospital Cologne, University of Cologne, 50935 Cologne, Germany.

Antioxidants (Basel, Switzerland)
|February 24, 2024
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NADPH oxidase 3 (Nox3) produces reactive oxygen species (ROS). This review explores Nox3

Keywords:
NADPH oxidaseNox3cardiovascular diseasescochleainner earlung diseasesototoxicityoxidative stressreactive oxygen speciesvestibular system

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Reactive oxygen species (ROS) were initially considered metabolic byproducts.
  • The discovery of NADPH oxidases (Nox) revealed enzymes specifically producing ROS.
  • Seven Nox isoforms have been identified, with Nox3 being notably understudied due to its initial discovery in the inner ear.

Purpose of the Study:

  • To comprehensively review the role of NADPH oxidase 3 (Nox3).
  • To investigate the validity of the notion that Nox3 is exclusively expressed in the inner ear.
  • To explore Nox3's function, regulation, and implications in health and disease.

Main Methods:

  • Literature review focusing on Nox3.
  • Analysis of Nox3 discovery, structure, and regulation.
  • Examination of Nox3 expression patterns and ROS production effects.

Main Results:

  • Nox3 is a key enzyme in ROS production.
  • Evidence suggests Nox3 expression extends beyond the inner ear.
  • Nox3-derived ROS have both beneficial and detrimental effects on physiological functions.

Conclusions:

  • Nox3's role is more widespread than previously assumed.
  • Understanding Nox3's dual role in ROS production is crucial.
  • Nox3 presents a potential therapeutic target for various diseases.