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Design and Synthesis of Immunoadjuvant QS-21 Analogs and Their Biological Evaluation
Wei Yuan1, Ziming Wang1, Yening Zou2
1State Key Laboratories of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Abstract:
A series of novel immunoadjuvant QS-21 analogs were synthesized, and their effects on the in vitro hemolysis of red blood cells were evaluated using QS-21 as a control and hemolytic properties as an index. Our results show that all the QS-21 analogs had lower hemolytic effects than QS-21, and their concentrations exhibited a certain quantitative effect relationship with the hemolysis rate. Notably, saponin compounds L1-L8 produced minimal hemolysis and showed lower hemolytic effects, warranting further investigation.
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