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Updated: Apr 9, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Asymmetric Synthesis of Chiral C3-Aminomethyl Cyclopentanones by Ene-Reductase-Catalyzed Kinetic Resolution via
Zheng Zhang1, Xina Du1, Guojun Zheng1
1State Key Laboratory of Chemical Resources Engineering, Beijing University of Chemical Technology, Beijing 100029, China.
Abstract:
Chiral C3-aminomethyl cyclopentanones are key intermediates in organic chemistry, yet their synthesis remains challenging. In this study, we present a kinetic resolution catalyzed by ene-reductases─OYE1 mutants─enabling C3-aminomethyl cyclopentanones to be resolved into R-C3-aminomethyl cyclopentanones (up to 99% e.e.) and corresponding α,β-unsaturated cyclopentanones via desaturation reactions. Remarkably, the reaction remains viable at the gram scale even with lower catalyst loadings, demonstrating potential for industrial-scale implementation.
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