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Navigating Precision Oncology: Insights from an Integrated Clinical Data and Biobank Repository Initiative across a
Bibek Aryal1, Zhadyra Bizhanova1, Edward A Joseph1
1Allegheny Singer Research Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.
Abstract:
Advancing cancer treatment relies on the rapid translation of new scientific discoveries to patient care. To facilitate this, an oncology biobank and data repository program, also referred to as the "Moonshot" program, was launched in 2021 within the Integrated Network Cancer Program of the Allegheny Health Network. A clinical data program (CDP) and biospecimen repository were established, and patient data and blood and tissue samples have been collected prospectively. To date, the study has accrued 2920 patients, predominantly female (61%) and Caucasian (90%), with a mean age of 64 ± 13 years. The most common cancer sites were the endometrium/uterus (12%), lung/bronchus (12%), breast (11%), and colon/rectum (11%). Of patients diagnosed with cancer, 34% were diagnosed at stage I, 25% at stage II, 26% at stage III, and 15% at stage IV. The CDP is designed to support our initiative in advancing personalized cancer research by providing a comprehensive array of patient data, encompassing demographic characteristics, diagnostic details, and treatment responses. The "Moonshot" initiative aims to predict therapy responses and clinical outcomes through cancer-related biomarkers. The CDP facilitates this initiative by fostering data sharing, enabling comparative analyses, and informing the development of novel diagnostic and therapeutic methods.
Insights
The Allegheny Health Network established a biobank and data repository in 2021 to advance cancer research. This program collects patient data and biospecimens to identify biomarkers for personalized cancer therapy and predict treatment outcomes.
Area of Science:
- Oncology
- Translational Research
- Biobanking
Background:
- Advancing cancer treatment requires swift translation of scientific discoveries into clinical practice.
- The Allegheny Health Network launched the "Moonshot" program in 2021 to accelerate this process.
- The program integrates a clinical data program (CDP) and a biospecimen repository.
Purpose of the Study:
- To establish a comprehensive oncology biobank and data repository.
- To collect prospective patient data and biospecimens for cancer research.
- To support the "Moonshot" initiative's goal of advancing personalized cancer research.
Main Methods:
- Prospective collection of clinical data and biospecimens from cancer patients.
- Establishment of a clinical data program (CDP) and biospecimen repository.
- Accrual of 2920 patients to date.
Main Results:
- The cohort comprises predominantly female (61%) and Caucasian (90%) patients, with a mean age of 64 ± 13 years.
- Common cancer sites include endometrium/uterus (12%), lung/bronchus (12%), breast (11%), and colon/rectum (11%).
- Cancer diagnoses occurred at various stages: Stage I (34%), Stage II (25%), Stage III (26%), and Stage IV (15%).
Conclusions:
- The CDP provides a rich dataset for personalized cancer research, including demographics, diagnostics, and treatment responses.
- The "Moonshot" initiative aims to predict therapy responses and clinical outcomes using cancer biomarkers.
- The CDP infrastructure facilitates data sharing, comparative analysis, and the development of novel diagnostics and therapeutics.
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