Risk Factor Analysis of Complications and Mortality Following Coil Procedures in Patients with Intracranial...

Area of Science:

• Neurosurgery
• Vascular Neurology
• Health Informatics

Background:

• Unruptured intracranial aneurysms (UIAs) are increasingly detected, with endovascular coiling becoming a common treatment.
• Coil treatment for UIAs carries risks of cerebral infarction (CI) and intracranial hemorrhage (ICRH).

Purpose of the Study:

• To analyze the incidence and risk factors of CI and ICRH following coil treatment for UIAs.
• To identify patient characteristics associated with increased complication and mortality risks.

Main Methods:

• Retrospective analysis of 35,140 patients treated with coils for UIAs from January 2015 to December 2021.
• Utilized the Health Insurance Review and Assessment (HIRA) database to assess patient characteristics and outcomes.
• Univariate analysis to identify risk factors for CI, ICRH, and mortality.

Main Results:

• Overall mortality rate was 1.8%. ICRH occurred in 1062 patients (8.2% mortality), and CI in 749 patients (3.9% mortality).
• Risk factors for CI included older age, male sex, higher Charlson Comorbidity Index (CCI), and diabetes.
• Risk factors for ICRH included male sex, higher CCI, and hemiplegia/paraplegia. Older age, male sex, and metastatic solid tumors were linked to higher mortality.

Conclusions:

• Patient's underlying medical conditions significantly influence complication risks after UIA coil treatment.
• Identifying high-risk patients can inform personalized treatment and management strategies.
• Further research into mitigating these specific risks is warranted.