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Microfabricated Nitinol Stent Retrievers with a Micro-Patterned Surface.

Shogo Kato1, Yuzuki Ban1, Takashi Ota1

  • 1Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

Micromachines
|February 24, 2024
PubMed
Summary
This summary is machine-generated.

Microfabricated nitinol stent retrievers with surface micro-patterns enhance mechanical thrombectomy for removing brain blood clots. These novel devices show improved blood clot retrieval efficacy in in vitro studies.

Keywords:
blood clotin vitromicrofabricationnitinolsputteringstent retrieverthrombectomythrombus

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neurosurgery

Background:

  • Mechanical thrombectomy is a critical procedure for treating acute ischemic stroke.
  • Current stent retrievers face challenges in effectively capturing and removing diverse blood clots.
  • Nitinol (nickel-titanium alloy) is a suitable material for stent retrievers due to its superelasticity and biocompatibility.

Purpose of the Study:

  • To develop and evaluate novel microfabricated nitinol stent retrievers with surface micro-patterns.
  • To investigate the impact of surface micro-patterns on the clot retrieval efficacy of nitinol stent retrievers.
  • To assess the feasibility of using sputtered nitinol films for fabricating advanced thrombectomy devices.

Main Methods:

  • Fabrication of a 20 µm thick nitinol film via sputtering onto a micro-patterned substrate.
  • Utilizing electroplated copper as a sacrificial layer for nitinol film release.
  • Thermal treatment of the released nitinol film in a folded cylindrical configuration.
  • In vitro testing using pig blood clots to evaluate retrieval performance.

Main Results:

  • Successful fabrication of micro-patterned nitinol films suitable for stent retriever construction.
  • Demonstrated enhanced blood clot retrieval efficacy in in vitro experiments compared to non-patterned surfaces.
  • The micro-patterns on the nitinol surface significantly improved the mechanical thrombectomy performance.

Conclusions:

  • Microfabrication of nitinol stent retrievers with surface micro-patterns is a viable approach to enhance thrombectomy.
  • Surface micro-patterns play a crucial role in improving the effectiveness of mechanical clot removal.
  • These findings suggest a promising new generation of stent retrievers for stroke treatment.