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Updated: Jul 2, 2025

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Microfabricated Nitinol Stent Retrievers with a Micro-Patterned Surface.

Shogo Kato¹, Yuzuki Ban¹, Takashi Ota¹

¹Department of Mechanical Engineering, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

|February 24, 2024

Summary

This summary is machine-generated.

Microfabricated nitinol stent retrievers with surface micro-patterns enhance mechanical thrombectomy for removing brain blood clots. These novel devices show improved blood clot retrieval efficacy in in vitro studies.

Keywords:

blood clot in vitro microfabrication nitinol sputtering stent retriever thrombectomy thrombus

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Last Updated: Jul 2, 2025

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Published on: September 18, 2015

Area of Science:

Biomedical Engineering
Materials Science
Neurosurgery

Background:

Mechanical thrombectomy is a critical procedure for treating acute ischemic stroke.
Current stent retrievers face challenges in effectively capturing and removing diverse blood clots.
Nitinol (nickel-titanium alloy) is a suitable material for stent retrievers due to its superelasticity and biocompatibility.

Purpose of the Study:

To develop and evaluate novel microfabricated nitinol stent retrievers with surface micro-patterns.
To investigate the impact of surface micro-patterns on the clot retrieval efficacy of nitinol stent retrievers.
To assess the feasibility of using sputtered nitinol films for fabricating advanced thrombectomy devices.

Main Methods:

Fabrication of a 20 µm thick nitinol film via sputtering onto a micro-patterned substrate.
Utilizing electroplated copper as a sacrificial layer for nitinol film release.
Thermal treatment of the released nitinol film in a folded cylindrical configuration.
In vitro testing using pig blood clots to evaluate retrieval performance.

Main Results:

Successful fabrication of micro-patterned nitinol films suitable for stent retriever construction.
Demonstrated enhanced blood clot retrieval efficacy in in vitro experiments compared to non-patterned surfaces.
The micro-patterns on the nitinol surface significantly improved the mechanical thrombectomy performance.

Conclusions:

Microfabrication of nitinol stent retrievers with surface micro-patterns is a viable approach to enhance thrombectomy.
Surface micro-patterns play a crucial role in improving the effectiveness of mechanical clot removal.
These findings suggest a promising new generation of stent retrievers for stroke treatment.