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Action Potential

Action Potential

Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...

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Related Experiment Video

Updated: Jul 2, 2025

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

Using Compound Neural Action Potentials for Functional Validation of a High-Density Intraneural Interface: A

Aritra Kundu^1,2, Erin Patrick², Seth Currlin³

¹Department of Bioengineering, Imperial College London, SW7 2AZ London, UK.

|February 24, 2024

Summary

This study introduces a novel electrode for nerve stimulation, using compound nerve action potentials (CNAPs) to assess performance. This technique offers a less invasive alternative to traditional methods, potentially reducing complications and improving recovery.

Keywords:

compound nerve action potentials intrafascicular electrodes peripheral nerve rat model

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Last Updated: Jul 2, 2025

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Published on: October 4, 2016

The DREAM Implant: A Lightweight, Modular, and Cost-Effective Implant System for Chronic Electrophysiology in Head-Fixed and Freely Behaving Mice

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Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond

Published on: June 24, 2015

Area of Science:

Neuroscience
Biomedical Engineering
Electrophysiology

Background:

Assessing neural interface performance is crucial for effective nerve stimulation.
Current methods often involve invasive procedures like EMG electrode implantation.
Minimizing surgical invasiveness can reduce complications and speed up recovery.

Purpose of the Study:

To evaluate the stimulation performance of a novel high-density, transverse, intrafascicular electrode.
To establish compound nerve action potentials (CNAPs) as a metric for assessing neural interface performance.
To demonstrate a less invasive method for approximating neural interface placement and orientation.

Main Methods:

Compound nerve action potentials (CNAPs) were recorded from distally implanted cuff electrodes in rat models.
CNAPs were analyzed as a function of stimulus current.
Recruitment plots were calculated to approximate electrode placement and orientation.

Main Results:

Characteristic CNAPs were successfully recorded, demonstrating electrode functionality.
Analysis of CNAPs provided a qualitative approximation of the neural interface's position within the nerve.
The method proved effective in assessing stimulation performance without requiring EMG electrodes.

Conclusions:

The novel electrode shows promising performance for nerve stimulation.
Using CNAPs offers a viable, less invasive method for evaluating neural interfaces.
This approach minimizes surgical trauma and may accelerate subject healing.