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Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study.

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Summary

This study investigated the causal link between gut bacteria and biological aging. It found that the bacterium Streptococcus is causally associated with accelerated biological aging, suggesting a potential role in the aging process.

Keywords:
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Area of Science:

  • Microbiology
  • Genetics
  • Gerontology

Background:

  • Observational studies suggest a link between gut microbiota composition and aging.
  • The causal relationship between gut microbiota and the aging process remains unclear.
  • Biological age acceleration is a key indicator of aging and healthspan.

Purpose of the Study:

  • To investigate the causal association between gut microbiota and biological age acceleration.
  • To identify specific gut bacteria that may influence the aging process.

Main Methods:

  • Employed a two-sample Mendelian randomization approach.
  • Utilized large-scale genome-wide association study (GWAS) summary data for gut microbiota (MiBioGen consortium) and biological age acceleration.
  • Conducted sensitivity analyses including MR-PRESSO, MR-Egger regression, Cochran Q test, and reverse MR analysis.

Main Results:

  • Streptococcus was found to be causally associated with biological age acceleration (IVW, β = 0.16, p = 0.0001).
  • Suggestive causal associations were observed for Eubacterium (rectale group), Sellimonas, and Lachnospira with biological age acceleration.
  • Actinomyces, Butyricimonas, and Lachnospiraceae (FCS020 group) showed suggestive causal associations with Phenoage acceleration.

Conclusions:

  • The Mendelian randomization study provides evidence for a causal role of Streptococcus in biological age acceleration.
  • Further research, including randomized controlled trials, is warranted to elucidate the specific mechanisms.
  • These findings contribute to understanding the gut microbiota's impact on aging.