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Updated: Jul 2, 2025

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
The bacterial pathogen Pseudomonas plecoglossicida, its epidemiology, virulence factors, vaccine development, and
Zhijuan Mao1, Shanshan Li1, Yiying Li1
1Biological and Environmental College, Zhejiang Wanli University, Ningbo, China.
Objective:
Pseudomoans plecoglossicida has been identified as a fish pathogen since 2000 and has caused serious infections in cultured Large Yellow Croakers Larimiththys crocea in coastal eastern China during recent years.
Methods:
Published literatures of this pathogen have been reviewed.
Result:
Several strains with high genomic similarity have been isolated and identified; the bacteria induce natural infection at lower water temperatures (12.0-25.5°C) and induce numerous granulomas and nodules in the visceral organs of croakers. Researchers have investigated the epidemiology of P. plecoglossicida infection, identified major virulence factors, searched for pathogenic genes, analyzed host-pathogen interactions, and endeavored to develop efficient vaccines.
Conclusion:
This paper provides an overview of these research advances to elucidate the virulence mechanisms of the pathogen and to promote vaccine development against infection.
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