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Medication Adherence Among Patients With Kidney Disease: An Umbrella Review
Wubshet Tesfaye1, Nicholas Parrish2, Kamal Sud3
1The University of Sydney School of Pharmacy, Sydney, New South Wales, Australia.
Advances in Kidney Disease and Health
|February 25, 2024
Summary
Medication nonadherence is common in chronic kidney disease (CKD), influenced by various factors. Interventions show varied success in improving adherence and patient outcomes.
Area of Science:
- Nephrology
- Pharmacology
- Public Health
Background:
- Chronic kidney disease (CKD) necessitates complex medication regimens.
- This medication burden impacts patient outcomes and quality of life.
Purpose of the Study:
- To provide a comprehensive overview of medication nonadherence in adults with CKD.
- To synthesize evidence on prevalence, risk factors, outcomes, and interventions for CKD medication nonadherence.
Main Methods:
- Umbrella review synthesizing data from systematic reviews and meta-analyses.
- Included 37 relevant published works.
- Categorized findings into prevalence, determinants, outcomes, and interventions.
Main Results:
- Medication nonadherence prevalence varies widely across CKD stages.
- Identified determinants include socioeconomic, clinical, and psychosocial factors.
- Interventions like nurse-led programs, pharmaceutical services, and eHealth showed mixed effectiveness.
Conclusions:
- Medication nonadherence is a significant issue in CKD management.
- Further research is needed on outcomes associated with nonadherence.
- Targeted interventions are crucial for improving adherence and self-management in CKD patients.
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