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Related Experiment Video

Updated: Jul 2, 2025

Bioinspired Soft Robot with Incorporated Microelectrodes
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Light-controlled soft bio-microrobot.

Jianyun Xiong1, Xing Li1, Ziyi He1

  • 1Guangdong Provincial Key Laboratory of Nanophotonic Manipulation, Institute of Nanophotonics, Jinan University, 511443, Guangzhou, China.

Light, Science & Applications
|February 25, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed light-controlled soft bio-microrobots (Ebots) from Euglena gracilis. These adaptable Ebots navigate narrow spaces for tasks like targeted drug delivery and cell removal in the intestine.

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Area of Science:

  • Biomedical Engineering
  • Micro-robotics
  • Synthetic Biology

Background:

  • Micro/nanorobots offer potential for biomedical applications but struggle with maneuverability in confined, deformable spaces.
  • Current micro/nanorobots lack the adaptability and deformability needed for complex tasks in challenging biological environments.

Purpose of the Study:

  • To develop a light-controlled soft bio-microrobot (Ebot) capable of performing multiple biomedical tasks in narrow, deformable microenvironments.
  • To enhance the controllability, deformability, and adaptability of micro-robots for intricate biomedical applications.

Main Methods:

  • Utilized Euglena gracilis as a base for soft bio-microrobots (Ebots).
  • Implemented light-controlled polygonal flagellum beating for precise navigation.
  • Demonstrated controlled deformability of Ebots by varying light illumination duration.

Main Results:

  • Ebots exhibited high controllability and adaptability in navigating narrow and curved microchannels.
  • Achieved precise motion control through light-induced flagellar responses.
  • Successfully demonstrated Ebots' ability to pass through challenging microenvironments.

Conclusions:

  • The light-controlled Ebot offers a novel bio-microrobotic tool for complex biomedical tasks in confined spaces.
  • Ebots possess high deformability and bio-adaptability, overcoming limitations of conventional micro/nanorobots.
  • Potential applications include targeted drug delivery, selective cell removal, and photodynamic therapy within intestinal mucosa.