Related Experiment Video

Updated: Jul 5, 2026

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
00:07

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation

Published on: August 30, 2019

9.0K

Autopsy of Drug-induced Lung Injury with Atypical Diffuse Alveolar Disorder due to Amiodarone

Hikaru Mamizu1, Hiroki Kohda1, Yuusuke Tomita1

  • 1Department of Internal Medicine, Niigata Prefectural Central Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|February 25, 2024
PubMed

Insights

Amiodarone, an antiarrhythmic drug, can cause severe lung injury. A case study highlights rapid respiratory failure and death in an elderly patient, emphasizing caution with this medication.

Area of Science:

  • Cardiology
  • Pulmonology
  • Toxicology

Background:

  • Amiodarone is a widely used antiarrhythmic medication.
  • Drug-induced lung injury (DILI) is a known but often underdiagnosed complication of amiodarone therapy.

Observation:

  • An 87-year-old male patient on amiodarone for 5 years presented with respiratory failure.
  • Chest CT showed bilateral lung consolidations with air bronchograms.
  • Despite aggressive steroid treatment, the patient's condition rapidly deteriorated.

Findings:

  • Autopsy confirmed amiodarone-induced lung injury.
  • Histopathology revealed hyaline membrane formation and fibrin deposition in alveolar spaces.
  • These findings indicate a severe and rapidly progressive form of DILI.

Implications:

  • Physicians should maintain a high index of suspicion for amiodarone-induced lung injury in patients presenting with respiratory distress.
  • The presence of fibrin deposition on autopsy may signify a poor prognosis and rapid clinical decline.
  • Careful patient monitoring and consideration of alternative treatments are crucial for patients on long-term amiodarone therapy.
Keywords:
acute fibrinous and organizing pneumoniaamiodaronediffuse alveolar damagedrug-induced lung injuryfibrin deposition

More Related Videos

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS06:22

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS

Published on: April 7, 2021

3.4K
Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death09:14

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death

Published on: October 18, 2024

424

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Atelectasis II: Pathophysiology01:10

Atelectasis II: Pathophysiology

Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through collapsed...