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Frequency And Risk Factors Of Microscopic Colitis As A Cause Of Chronic Watery Diarrhoea
Sabhita Shabir Shaikh1, Raheela Khalid1, Uzma Bukhari1
1Dow University of Health Sciences, Karachi, Pakistan.
Microscopic colitis (MC) affects 3.4% of chronic watery diarrhea cases in Pakistan. This study identified MC variants and a potential link to autoimmune diseases, highlighting the need for further research.
Area of Science:
- Gastroenterology
- Pathology
Background:
- Microscopic colitis (MC) is a significant cause of chronic watery diarrhea, often underdiagnosed globally.
- This study represents the first investigation into MC prevalence and risk factors within Pakistan.
Purpose of the Study:
- To determine the frequency of microscopic colitis in Pakistani patients presenting with chronic watery diarrhea.
- To explore potential risk factors associated with microscopic colitis in this population.
Main Methods:
- A prospective, cross-sectional study was conducted at a tertiary care hospital in Pakistan.
- 58 participants with chronic watery diarrhea and normal colonoscopy findings were enrolled.
- Biopsies were analyzed to diagnose microscopic colitis.
Main Results:
- Microscopic colitis was diagnosed in 3.4% (2 out of 58) of participants.
- The diagnosed cases included lymphocytic colitis and collagenous colitis variants.
- The average MC scoring system score was 7.53 for the study group.
Conclusions:
- The prevalence of microscopic colitis in Pakistan is estimated at 3.4% among chronic watery diarrhea cases.
- An association between microscopic colitis and autoimmune diseases was observed.
- A larger sample size is recommended for future studies to provide a comprehensive understanding of MC.
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