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Proteomics and Its Current Application in Biomedical Area: Concise Review.
Semira Gobena1, Bemrew Admassu2, Mebrie Zemene Kinde2
1College of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia.
Proteomics, the study of proteins, is vital for biomedical research, aiding in disease diagnosis and drug discovery. Understanding protein structure and function drives advancements in human and animal health.
Area of Science:
- Biomedical research
- Proteomics
Background:
- Biomedical research seeks advanced technologies for disease diagnosis, drug discovery, and therapies.
- Proteomics is a key technology for studying protein composition, structure, function, and interactions.
Purpose of the Study:
- To provide a comprehensive overview of proteomics.
- To outline current applications of proteomics in the biomedical domain.
- To emphasize proteomics' role in advancing biomedical research and therapeutics.
Main Methods:
- Polyacrylamide gel electrophoresis
- Mass spectrometry analysis
- NMR spectroscopy
- Protein microarray
- X-ray crystallography
- Edman sequencing
Main Results:
- Proteomics aids in understanding biological systems through expression, structural, and functional studies.
- Applications include cancer research, stem cell studies, infectious/non-infectious disease research, and personalized medicine.
- Proteomics is crucial for drug discovery and developing innovative therapeutic approaches.
Conclusions:
- Proteomics is indispensable for unraveling molecular mechanisms in health and disease.
- The significance of proteomics grows with emerging diseases and expanding biomedical research.
- Staying updated on proteomics applications is crucial for therapeutic development and translational research.
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