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Synthesis and Spectroscopic Characterization of Schiff Base Metal Complexes, Biological Activity, and Molecular
Ganesan Venkatesh1, Palanisamy Vennila2, Savas Kaya3
1Department of Chemistry, Muthayammal Memorial College of Arts and Science, Namakkal, Tamil Nadu 637408, India.
ACS Omega
|February 26, 2024
Summary
New Schiff metal complexes of cobalt, copper, and zinc were synthesized and characterized. These compounds exhibit promising antioxidant, antifungal, and antibacterial activities, with potential applications in breast cancer therapy.
Area of Science:
- Coordination Chemistry
- Materials Science
- Medicinal Chemistry
Background:
- Schiff bases are versatile ligands in coordination chemistry.
- Metal complexes often exhibit enhanced biological activities compared to their ligands.
- Exploring novel metal complexes for therapeutic applications is crucial.
Purpose of the Study:
- Synthesize and characterize novel cobalt(II), copper(II), and zinc(II) Schiff metal complexes.
- Investigate the biological activities, including antioxidant, antifungal, and antibacterial properties.
- Explore potential applications in breast cancer treatment through molecular docking studies.
Main Methods:
- Condensation reaction for Schiff base ligand synthesis.
- Characterization using spectroscopic (FTIR, NMR, UV-Vis, EPR) and analytical techniques (MS, XRD).
- Electrochemical analysis via cyclic voltammetry and computational modeling (DFT).
Main Results:
- Successful synthesis and full characterization of H2L ligand and its Co(II), Cu(II), Zn(II) complexes.
- Demonstrated significant antioxidant, antifungal, and antibacterial activities of the synthesized compounds.
- Computational studies provided insights into electronic structures and molecular properties.
- Molecular docking revealed potential interactions with HER2 target proteins relevant to breast cancer.
Conclusions:
- The synthesized Schiff metal complexes represent a novel class of compounds with diverse properties.
- These complexes show potential as antimicrobial and antioxidant agents.
- Further investigation into their therapeutic efficacy, particularly in breast cancer, is warranted.
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