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Updated: Jul 2, 2025

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues
Published on: August 23, 2024
Novel BRAF N581S mutation in mantle cell lymphoma
Nisha Hariharan1, Davsheen Bedi2, Michael Y Choi1
1Division of Hematology/Oncology Department of Medicine University of California San Diego La Jolla California USA.
Abstract:
BRAF mutations are associated with a small number of hematologic malignancies, including hairy cell leukemia and histiocytic disorders. In addition, BRAF mutations have also been detected in low frequency in other B-cell lymphomas, such as chronic lymphocytic leukemia and diffuse large B-cell lymphoma, but never in mantle cell lymphoma (MCL). We present a case of a 69-year-old female with classic MCL harboring a BRAFN581S mutation. To our knowledge, this is the first reported case of any BRAF mutation in MCL.
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