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Immune reconstitution inflammatory syndrome-associated lymphoma: A retrospective Brazilian cohort

Juliano Cordova Vargas^1,2,3, Karin Zattar Cecyn¹, Mariana de Oliveira Marques^1,4

¹Department of Clinical and Experimental Oncology Federal University of São Paulo São Paulo SP Brazil.

|February 26, 2024

Abstract:

After initiating combined antiretroviral therapy (cART), individuals with human immunodeficiency virus (HIV) may develop Hodgkin/non-Hodgkin lymphoma due to immune reconstitution inflammatory syndrome (IRIS). This retrospective cohort study evaluated the incidence, clinical features and prognosis of IRIS-associated lymphomas in Brazilian patients. Incidence in 2000-2019 was 9.8% (27/276 patients with HIV and lymphoma; viral load drop >1 log). Time between HIV diagnosis and cART initiation was <1 year in 70.3% of cases. Time between cART initiation and lymphoma diagnosis was <3 months in 11 cases and 3-6 months in 16 cases. Overall and progression-free survival rates were similar between cases of non-IRIS-associated lymphoma and IRIS-associated lymphoma.

Keywords:

antiretroviral therapy immune reconstitution inflammatory syndrome lymphoma

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